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Relevant Articles

Traynor-Kaplan, A.E., M. Moody, C. Schultz (2005) "An inositol phosphate analog, ino-4995 normalizes electrophysiology in CF Airway Epithelia." Advances in Experimental Biology, 558:115-127. (pdf)

Moody, M., C. Pennington, C. Schultz, R. Caldwell, C. Dinkel, M. Rossi, S. McNamara, J. Widdicombe, S. Gabriel, and A. E. Traynor-Kaplan (2005) "Inositol polyphosphate derivative inhibits Na+ transport and improves fluid dynamics in cystic fibrosis airway epithelia." Am J Physiol Cell Physiol 289: C512–C520, 2005 (pdf)

Drumm, M., Kyle, N., Moody, M., Traynor Kaplan, A., Langton-Webster, B. (2004) "INO-4995, A candidate Cystic Fibrosis therapy, decreases nasal potential difference in a mouse CF model." Pediatric Pulmonology Vol 38. Suppl. 26 p 254 (pdf)

Duerson, K., Moody, M., Schultz, C., Traynor-Kaplan, Alexis (2004)"A De-esterified form of INO-4995, (INO-4913) stimulates whole cell Cl- currents in CF human nasal epithelial cells." Pediatric Pulmonology Vol 38 Suppl 27 p 241-242 (pdf)

Traynor-Kaplan, A., Moody, M., Pennington, C., Langton-Webster, B. (2003) “Preclinical Profile of an inositol polyphosphate analog, INO-4995, a candidate therapeutic for cystic fibrosis." Pediatric Pulmonology Vol. 36. Suppl 25:p248.

Widdicombe, J. and Traynor-Kaplan, A. (2003) “An inositol polyphosphate analog, INO-4995, inhibits salt and water absorption across CF airway epithelia." Pediatric Pulmonology Vol. 36. Suppl 25:p209.

Rudolf, M. T., Dinkel, C., Traynor-Kaplan, A.E., Schultz, C. (2003) "Antagonists of myo-inositol 3,4,5,6-tetrakisphosphate allow repeated epithelial chloride secretion." Biorg. Med. Chem.,11:3315-3329. (pdf)

Moody, M., C. Dinkel, C. Schultz, A. Traynor-Kaplan, (2002) “INO-E2 Inhibits fluid absorption in CF Nasal Epithelial Cells“ Pediatric Pulmonology Vol. 34. Suppl 24. p214.

Moody, M., Duerson, K., Dinkel, C., Pennington, C., Schultz, C., Traynor-Kaplan, A. (2001) "A membrane-permeant analog of inositol 3,4,5,6-tetrakisphosphate inhibits Na+ absorption in CF nasal epithelia." Pediatric Pulmononology, Vol 32, Suppl. 22: 258.

Dinkel, C Moody, M., Traynor-Kaplan, A. and Schultz, C. (2001) "Membrane-Permeant 3-OH-Phosphorylated Phosphoinositide Derivatives" Angew. Chem. Int. Ed. , 40, No. 16: 3004-8.

Duerson, K., M. Moody, A. Schnaars, C. Schultz, A.E. Traynor-Kaplan. (2000) “Patch clamp analysis of Cl- current stimulated by a membrane-permeant Inositol polyphosphate analogue in CF Nasal epithelial cells.” Pediatric Pulmonology Vol. 30 Suppl. 20: 206.

Eckmann, L.E., M.R.Rudolf, A.Ptasznik , C.Schultz , T.Jiang, N.Wolfson, R.Tsien, J.Fierer, S.B.Shears, M.F.Kagnoff, & A.E.Traynor-Kaplan (1997) "D-myo-Inositol 1,4,5,6-tetrakisphosphate produced in human intestinal epithelial cells in response to Salmonella invasion inhibits phosphoinositide 3 kinase signaling pathways" Proc.Natl.Acad.Sci, USA 94:14456-14460. (pdf)

Jiang, T., G. Sweeney, M. Rudolf, A. Klip, A. Traynor-Kaplan, and R.Y.Tsien (1998) "Membrane-permeant esters of phosphatidylinositol-3,4,5-trisphosphate." J. Biol. Chem. 273:11017-24.

Rudolf, M.T., W. Li, N. Wolfson, A.E. Traynor-Kaplan, and C. Schultz. (1998) "Deoxy derivatives are partial agonists of the intracellular messenger inositol 3,4,5,6- tetrakisphosphate in the epithelia cell line T84." J. Med. Chem. 41:3655

Rudolf, M.T., Traynor-Kaplan, A.E., and Schultz, C. (1998). "A membrane-permeant, bioactivatable derivative of Ins(1,3,4)P3 and its effect on Cl(-)-secretion from T84 cells". Bioorg Med Chem Lett 8, 1857-60. (pdf)

Schultz, C., Rudolf, M. T., Gillandt, H. H., Traynor-Kaplan, A.E., (1999) "Membrane-permeant, bioactivatable derivatives of inositol polyphosphates and phosphoinositides." In: Phosphoinositides: Chemistry, Biochemistry and Biomedical Applications, K. S. Bruzik, Ed. Am. Chem. Soc., Symp. Ser. 718, 232-243.

Vajanaphanich, M., C. Schultz, M.T. Rudolf, M. Wasserman, P. Enyedi, A. Craxton, R. Tsien, S.B. Shears, K.E. Barrett, A.E. Traynor-Kaplan. (1994). "Long-term uncoupling of chloride secretion from intracellular calcium levels by Ins(3,4,5,6)P4." Nature 371: 711-714.

Dobos, G.J., Wu, X.R., Traynor-Kaplan, A. (1993) "A product of phosphatidyleinositol-3 kinase is elevated in dividing HT29 colonic epithelial cells." FEBS Lett. 324: 143-146. (pdf)

Eberle, M., Traynor-Kaplan, A.E., Sklar, L.A., Norgauer, J. (1990) "Is There a Relationship between Phosphatidylinositol Trisphosphate and F-actin Polymerization in Human Neutophils?" J. Biol. Chem. 265: 16725-16728. (pdf)

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Stephen B. Shears (2005) "Can intervention in inositol phosphate signalling pathways
improve therapy for cystic fibrosis?" Expert Opin. Ther. Targets 9(6):1307-1317. (pdf)

Robin F. Irvine and Michael J. Schell (2001) "Back in the Water: The Return of the Inositol Phosphates" Nature Reviews/Molecular Cell Biology Vol 2:327-338. (pdf)

Christopher P. Berrie and Marco Falasca (2000) "Patterns within protein/polyphosphoinositide interactions provide specific targets for therapeutic intervention" FASEB Journal 14:2618-2622. (pdf)

Wenhong Li, Carsten Schultz, Juan Llopis, Roger Y. Tsien (1997) "Membrane-Permeant Esters of Inositol Polyphosphates, Chemical Syntheses and Biological Applications" Tetrahedron, Vol. 53, No. 35, pp. 12017-12040. (pdf)